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CloseSerenity is a product designed to normalize excessive physical and mental stress through multiple mechanisms of regulating cortisol activity View Supplement Info
WHAT IS IT?
Serenity is a product designed to normalize excessive physical and mental stress through multiple mechanisms of regulating Cortisol activity. We’ve combined Phosphatidylserine with Quercetin and Magnolol/Honokiol to help regulate cortisol activity and decrease stress. Finally, Serenity also contains a new trademarked form of Ashwagandha named Shoden®, which actually contains 35% Withanolides, which is currently the highest standardization available in nutritional supplements.
WHY WOULD I TAKE IT?
Sometimes either excessive psychological stress or overtraining can cause an increase in a catabolic hormone, Cortisol. Cortisol can cause decrements in muscle tissue and also make the body more susceptible to storing fat. Cortisol is a stress hormone that can also cause alterations in mood or judgement. That’s why we’ve created Serenity - to dampen the effects of excessive cortisol and improve mood and sense of well-being.
HOW DOES THIS WORK?
Serenity works by modulating three separate mechanisms within the cortisol production pathway. The leading hypothesis on Phosphatidylserine is that it has an inhibitory effect on secretion of ACTH (Adrenocorticotropic hormone) - which actually stimulates cortisol production. Secondly, in an attempt to inhibit 11-beta hydroxysteroid dehydrogenase we’ve employed Quercetin and Magnolol to block this enzyme’s ability to convert cortisone into cortisol. Quercetin also utilizes a secondary mechanism that inhibits steroid 11β-hydroxylase, which is an enzyme that creates cortisol from 11-deoxycorticosterone. Then finally, we utilize Shoden®, a form of Ashwagandha with 35% Withanolide content to also support further stress reduction.
HOW MUCH SHOULD I TAKE?
Serenity is best taken approximately one hour before desired effect to relieve stress - 3 capsules per serving. Please note: do not exceed three doses in 24 hours.
TOP 5 STUDIES:
1 - An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
2 - A randomized, double-blind, placebo-controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
https://www.sciencedirect.com/science/article/abs/pii/S1389945720301246
3 - Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.
https://www.sciencedirect.com/science/article/pii/S0041008X11004534
4 - A Novel 11β‐Hydroxysteroid Dehydrogenase Inhibitor Contained in Saiboku‐To, a Herbal Remedy for Steroid‐dependent Bronchial Asthma.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1994.tb03799.x
5 - Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males.
