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CloseSerenity is a product designed to normalize excessive physical and mental stress through multiple mechanisms of regulating cortisol activity View Supplement Info
WHAT IS IT?
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Serenity is a product designed to normalize excessive physical and mental stress through multiple mechanisms of regulating Cortisol activity. Weâve combined Phosphatidylserine with Quercetin and Magnolol/Honokiol to help regulate cortisol activity and decrease stress. Finally, Serenity also contains a new trademarked form of Ashwagandha named ShodenÂŽ, which actually contains 35% Withanolides, which is currently the highest standardization available in nutritional supplements.
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WHY WOULD I TAKE IT?
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Sometimes either excessive psychological stress or overtraining can cause an increase in a catabolic hormone, Cortisol. Cortisol can cause decrements in muscle tissue and also make the body more susceptible to storing fat. Cortisol is a stress hormone that can also cause alterations in mood or judgement. Thatâs why weâve created Serenity - to dampen the effects of excessive cortisol and improve mood and sense of well-being.
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HOW DOES THIS WORK?
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Serenity works by modulating three separate mechanisms within the cortisol production pathway. The leading hypothesis on Phosphatidylserine is that it has an inhibitory effect on secretion of ACTH (Adrenocorticotropic hormone) - which actually stimulates cortisol production. Secondly, in an attempt to inhibit 11-beta hydroxysteroid dehydrogenase weâve employed Quercetin and Magnolol to block this enzymeâs ability to convert cortisone into cortisol. Quercetin also utilizes a secondary mechanism that inhibits steroid 11β-hydroxylase, which is an enzyme that creates cortisol from 11-deoxycorticosterone. Then finally, we utilize ShodenÂŽ, a form of Ashwagandha with 35% Withanolide content to also support further stress reduction.
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HOW MUCH SHOULD I TAKE?
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Serenity is best taken approximately one hour before desired effect to relieve stress - 3 capsules per serving. Please note: do not exceed three doses in 24 hours.
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TOP 5 STUDIES:
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1 - An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
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2 - A randomized, double-blind, placebo-controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
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https://www.sciencedirect.com/science/article/abs/pii/S1389945720301246
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3 - Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.
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https://www.sciencedirect.com/science/article/pii/S0041008X11004534
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4 - A Novel 11βâHydroxysteroid Dehydrogenase Inhibitor Contained in SaibokuâTo, a Herbal Remedy for Steroidâdependent Bronchial Asthma.
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https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1994.tb03799.x
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5 - Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males.
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